males especially

Normal numbers of male and female gametocytes are produced. Both male and female gametocytes showed a strong reduction in egress from the host erythrocyte, resulting in strongly decreased fertilisation rates.

Normal numbers of male and female gametocytes are produced. Both male and female gametocytes showed a strong reduction in egress from the host erythrocyte, resulting in strongly decreased fertilisation rates.

Normal or slightly reduced gametocyte production. The ratio male to female gametocytes in the mutant is comparable to that in wild type. The proportion of macrogametes which activate to express Pb28 on the surface is significantly reduced (27% of wild-type). Slightly reduced male gametocyte exflagellation.

Gametocytes were strongly impaired in their capacity to produce mature ookinetes. Although small numbers of ookinetes were formed, they represented at most 6% (range 06%) of the ookinete production observed in wild type parasites. The small number of ookinetes produced normal oocysts and infectious sporozoites.

Gametocytes were strongly impaired in their capacity to produce mature ookinetes. Although small numbers of ookinetes were formed, they represented at most 6% (range 06%) of the ookinete production observed in wild type parasites. The small number of ookinetes produced normal oocysts and infectious sporozoites.

Strongly reduced ookinete production (11-17% of wild type).

Strongly reduced oocyst formation (10% of wild type numbers).

Strongly reduced sporozoite production (28% of wild type numbers). Sporozoites were infective to mice.