Compartmentalization of PfYkt6.1 in P. falciparum parasites. Trophozoite stage parasites exhibiting increased targeting of the PfYkt6.1 protein to organellar compartments were by confocal immunofluorescence microscopy using various organellar markers. (A) Immunofluorescence micrograph showing complete overlap between the GFP fluorescence and anti-PfYkt6.1 antibody signal in GFP-PfYkt6.1 expressing parasites. The GFP-PfYkt6.1 compartments were only partially labeled with antibodies against the Golgi marker PfErd2 (B), or the ER marker PfBip (C). Scale bars, 2μM. PfYkt6.1 appeared to be partly cytosolic and partly membrane-associated inside the parasite cytoplasm,Ayong L, Dasilva T, Mauser J, Allen CM, Chakrabarti D. Evidence for Prenylation-Dependent Targeting of a Ykt6 SNARE in Plasmodium falciparum. Mol Biochem Parasitol. 2010 175(2):162-8. Copyright Elsevier 2011.