PF3D7_0525900 NIMA related kinase 2 (NEK2)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. falciparum 3D7 |
Possible |
22127061 | Theo Sanderson, Wellcome Trust Sanger Institute | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. berghei ANKA |
Possible |
RMgm-294 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
RMgm-288 | Imported from RMgmDB | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
RMgm-294 | Imported from RMgmDB |
| P. berghei ANKA | Asexual |
No difference |
RMgm-288 | Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-294 | Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-288 | Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
Difference from wild-type |
RMgm-294
Male (micro) gametocytes are able to exflagellate as efficiently as wild-type parasites and female (macro)gametocytes emerge normally. Fertilisation occurs, but development is arrested at the 2N zygote stage. The defect is female gamete specific; male gametes are fertile and able to fertilize wild-type female gametes. |
Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
Difference from wild-type |
RMgm-288
Male (micro) gametocytes are able to exflagellate as efficiently as wild-type parasites and female (macro)gametocytes emerge normally. Fertilisation occurs, but development is arrested at the 2N zygote stage. The defect is female gamete specific; male gametes are fertile and able to fertilize wild-type female gametes. |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-288
Fertilisation of female gametes occurs, but development is arrested at the 2N zygote stage and no mature ookinetes are formed. No oocyst are formed in Anopheles stephensi mosquitoes. |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-294
Fertilisation of female gametes occurs, but development is arrested at the 2N zygote stage and no mature ookinetes are formed. No oocyst are formed in Anopheles stephensi mosquitoes. |
Imported from RMgmDB |
Imaging data (from Malaria Metabolic Pathways)
Transgenic expression of GFP-tagged Pfnek-4 and Pfnek-2 proteins in P. falciparum parasites. Live images of Hoechst-stained P. falciparum 3D7 transfectants episomally expressing Pfnek-2-GFP (A) or Pfnek-4-GFP (B) proteins under cognate Pfnek-2 and Pfnek-4 promoters, respectively. A. The Pfnek-2-GFP fluorescence (green) is not observed in stage II gametocytes (G-II), but appears to be associated to microtubule structures in more mature stage IV gametocytes (G-IV). B. The Pfnek-4-GFP fluorescence (green) appears as single dots associated with Hoechst-stained nuclear bodies (blue) in a subset of schizonts (S) and stage II gametocytes (G-II). DIC images are shown as well.Doerig C, Reininger L. Nima- and Aurora-related kinases of malaria parasites. Biochim Biophys Acta. 2013 1834(7):1336-45
See original on MMPMore information
| PlasmoDB | PF3D7_0525900 |
| GeneDB | PF3D7_0525900 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | MAL5P1.258, PFE1290w |
| Orthologs | PBANKA_1240700 , PCHAS_1241100 , PKNH_1006900 , PVP01_1007900 , PVX_079950 , PY17X_1243900 |
| Google Scholar | Search for all mentions of this gene |