| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. falciparum 3D7 |
Possible |
29873127 No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts. |
Theo Sanderson, Wellcome Trust Sanger Institute | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. berghei ANKA |
Possible |
RMgm-4173 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
RMgm-4458 | Imported from RMgmDB | |
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. falciparum 3D7 | Asexual |
No difference |
29873127 No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts. |
Theo Sanderson, Wellcome Trust Sanger Institute |
| P. falciparum 3D7 | Gametocyte |
No difference |
29873127 No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts. |
Theo Sanderson, Wellcome Trust Sanger Institute |
| P. falciparum 3D7 | Ookinete |
Attenuated |
29873127 No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts. |
Theo Sanderson, Wellcome Trust Sanger Institute |
| P. falciparum 3D7 | Oocyst |
Attenuated |
29873127 No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts. |
Theo Sanderson, Wellcome Trust Sanger Institute |
| P. berghei ANKA | Asexual |
No difference |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. berghei ANKA | Asexual |
No difference |
RMgm-4173 | Imported from RMgmDB |
| P. berghei ANKA | Asexual |
No difference |
RMgm-4458 | Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-4173 | Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-4458 | Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
No difference |
RMgm-4173 | Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-4173
Normal ookinete production. Normal ookinete motility. Significantly reduced oocyst numbers/production. |
Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
Difference from wild-type |
RMgm-4173
Normal ookinete production. Significantly reduced oocyst numbers/production.Significantly reduced salivary gland numbers/production. Sporozoites were infective to mice as shown by bite-back experiments |
Imported from RMgmDB |
| P. berghei ANKA | Liver |
Difference from wild-type |
RMgm-4173
Significantly reduced salivary gland numbers/production. Sporozoites were infective to mice as shown by bite-back experiments |
Imported from RMgmDB |
| PlasmoDB | PF3D7_0507300 |
| GeneDB | PF3D7_0507300 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | MAL5P1.74, PFE0360c |
| Orthologs | PBANKA_1106900 , PCHAS_1106600 , PKNH_1026300 , PVP01_1026700 , PVX_097925 , PY17X_1108000 |
| Google Scholar | Search for all mentions of this gene |