| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
RMgm-5076 | Imported from RMgmDB | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. falciparum 3D7 |
Possible |
36477538 Essentially no males observed from straight knockout. In addition: \'We show that Md1 has a dual function stemming from two separate domains: in sex determination through its N terminus and in male development from its conserved C-terminal LOTUS/OST-HTH domain. We further identify a bistable switch at the md1 locus, which is coupled with sex determination and ensures that the male-determining gene is not expressed in the female lineage.\' |
Theo Sanderson, Francis Crick Institute | |
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
RMgm-5076 | Imported from RMgmDB |
| P. falciparum 3D7 | Asexual |
No difference |
36477538 Essentially no males observed from straight knockout. In addition: \'We show that Md1 has a dual function stemming from two separate domains: in sex determination through its N terminus and in male development from its conserved C-terminal LOTUS/OST-HTH domain. We further identify a bistable switch at the md1 locus, which is coupled with sex determination and ensures that the male-determining gene is not expressed in the female lineage.\' |
Theo Sanderson, Francis Crick Institute |
| P. berghei ANKA | Gametocyte |
Difference from wild-type |
RMgm-5076
No males, fertile females. |
Imported from RMgmDB |
| P. falciparum 3D7 | Gametocyte |
Difference from wild-type |
36477538 Essentially no males observed from straight knockout. In addition: \'We show that Md1 has a dual function stemming from two separate domains: in sex determination through its N terminus and in male development from its conserved C-terminal LOTUS/OST-HTH domain. We further identify a bistable switch at the md1 locus, which is coupled with sex determination and ensures that the male-determining gene is not expressed in the female lineage.\' |
Theo Sanderson, Francis Crick Institute |
| P. berghei ANKA | Ookinete |
Difference from wild-type |
RMgm-5076
No males, fertile females.Complete (or nearly complete) loss in the ability to form oocysts in mosquitoes |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-5076
Complete (or nearly complete) loss in the ability to form oocysts in mosquitoes |
Imported from RMgmDB |
| PlasmoDB | PCHAS_1305900 |
| GeneDB | PCHAS_1305900 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PC000151.02.0, PC000796.00.0, PC102425.00.0, PCAS_130590, PCHAS_130590 |
| Orthologs | PBANKA_1302700 , PF3D7_1438800 , PKNH_1243500 , PVP01_1268200 , PVX_118550 , PY17X_1306500 |
| Google Scholar | Search for all mentions of this gene |