PCHAS_1245700 formin 1, putative
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. falciparum 3D7 | Asexual |
Refractory |
37596377 (Conditional)
Essential for merozoite invasion. Delay in gam formation. DiCre approach |
Theo Sanderson, Francis Crick Institute |
| P. falciparum 3D7 | Gametocyte |
Difference from wild-type |
37596377 (Conditional)
Essential for merozoite invasion. Delay in gam formation. DiCre approach |
Theo Sanderson, Francis Crick Institute |
Imaging data (from Malaria Metabolic Pathways)
Schizont and merozoite culture was incubated overnight with 0.1µM cytochalasin D to inhibit invasion. Thin smeared on a glass slide, fixed in methanol, stained with Rabbit anti-formin1 polyclonal serum 1:300. Formin1 localizes to extreme apex of merozoite and follows tight junction (not shown).Baum J, Tonkin CJ, Paul AS, Rug M, Smith BJ, Gould SB, Richard D, Pollard TD, Cowman AF. A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion. Cell Host Microbe. 2008 3:188-98. Copyright Elsevier 2009.
See original on MMPMore information
| PlasmoDB | PCHAS_1245700 |
| GeneDB | PCHAS_1245700 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PC000770.02.0, PC301809.00.0, PC402473.00.0, PCAS_124570, PCHAS_124570 |
| Orthologs | PBANKA_1245300 , PF3D7_0530900 , PKNH_1001800 , PVP01_1002900 , PVX_079720 , PY17X_1248800 |
| Google Scholar | Search for all mentions of this gene |