PCHAS_1221000 lysophospholipase, putative
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. falciparum 3D7 | Asexual |
No difference |
28106035 (Spontaneous loss, not experimental genetics)
Truncation |
Theo Sanderson, Wellcome Trust Sanger Institute |
Imaging data (from Malaria Metabolic Pathways)
PfPARE is expressed in asexual parasites. Live fluorescence microscopy with GFP-tagged PfPARE shows the protein is in the cytoplasm. Scale bar 5 mm. The intensity of the GFP fluorescence was weak in ring stages and increased with parasite maturity.Istvan ES, Mallari JP, Corey VC, Dharia NV, Marshall GR, Winzeler EA, Goldberg DE. Esterase mutation is a mechanism of resistance to antimalarial compounds. Nat Commun. 2017 8:14240.
See original on MMPMore information
| PlasmoDB | PCHAS_1221000 |
| GeneDB | PCHAS_1221000 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PC000199.01.0, PC000801.00.0, PCAS_122100, PCHAS_122100 |
| Orthologs | PBANKA_1220300 , PF3D7_0709700 , PKNH_0108400 , PVP01_0110100 , PVX_088015 , PY17X_1223500 |
| Google Scholar | Search for all mentions of this gene |