The phenotype of this mutant has not been analysed in detail. Analyses of other mutants lacking expression of LISP1 (RMgm-237, RMgm-279, RMgm-280) indicate that egress of merozoites from the mature liver schizont is impaired

By analysis of blood stage parasitemia after intravenous injection of sporozoites, the mutant sporozoites showed a 15-fold decrease in infectivity.The number and size of liver schizonts in rats and in HepG2 cells of the mutant was comparable to those of wild type parasites. The number of merozoites in mutant liver schizonts was similar to the merozoite number in wild type schizonts. The number of merozoites released from liver schizonts was 10-fold reduced compared to wild type. Released mutant merozoites showed an infectivity to erythrocytes that was comparable to that of wild type merozoites.

By analysis of blood stage parasitemia after intravenous injection of sporozoites, the mutant sporozoites showed a 15-fold decrease in infectivity.The number and size of liver schizonts in rats and in HepG2 cells of the mutant was comparable to those of wild type parasites.

By analysis of blood stage parasitemia after intravenous injection of sporozoites, the mutant sporozoites showed a 15-fold decrease in infectivity.