Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-4447 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-4447 Imported from RMgmDB
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Difference from wild-type
RMgm-4447
Reduced growth rate of asexual blood stages (the PHBL-deficient mutant grew at only 37% of the wild-type (WT) rate.Reduced virulence (no cerebral complications in infected mice)
Imported from RMgmDB
P. berghei ANKA Asexual
Difference from wild-type
RMgm-4447
Reduced growth rate of asexual blood stages (the PHBL-deficient mutant grew at only 37% of the wild-type (WT) rate.Reduced virulence (no cerebral complications in infected mice)
Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-4447 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-4447 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-4447
Reduced formation of ookinetes in vitro. The ookinetes that were formed in vitro displayed normal gliding motility.No ookinete formation could be detected in vivo (in midguts of A stephensi)
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-4447
Reduced formation of ookinetes in vitro. The ookinetes that were formed in vitro displayed normal gliding motility.No ookinete formation could be detected in vivo (in midguts of A stephensi)
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4447
No oocyst formation
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4447
No oocyst formation
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-4447
No oocyst and sporozoite formation
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-4447
No oocyst and sporozoite formation
Imported from RMgmDB

More information

PlasmoDB PCHAS_0727700
GeneDB PCHAS_0727700
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000104.03.0, PC302166.00.0, PCAS_072770, PCHAS_072770
Orthologs PBANKA_0718600 , PF3D7_0416600 , PKNH_0509000 , PVP01_0526000 , PVX_089920 , PY17X_0718800
Google Scholar Search for all mentions of this gene