Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Cell cycle arrest
https://www.biorxiv.org/content/10.1101/2021.11.01.466802v1 (Knock down)
Growth arrest before schizogony but \"no effect on protein export or acetylation of the exported proteins HRP2 and HRP3. Pf3D7_1437000-depleted parasites arrested later in their development cycle than export-blocked parasites, suggesting the protein’s essential role is distinct from protein export.\"
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Asexual
36744402 (Conditional)
\"Here, we used inducible gene deletion and post-transcriptional knockdown to investigate the primary ER-resident NAT candidate, Pf3D7_1437000. We found that it localizes to the ER and is required for parasite growth. However, depletion of Pf3D7_1437000 had no effect on protein export or acetylation of the exported proteins HRP2 and HRP3. Despite this, Pf3D7_1437000 depletion impedes parasite development within the host red blood cell and prevents parasites from completing genome replication\"
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PCHAS_0613500
GeneDB PCHAS_0613500
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000449.04.0, PC000597.00.0, PC302531.00.0, PCAS_061230, PCHAS_061350
Orthologs PBANKA_0611800 , PF3D7_1437000 , PKNH_0423600 , PVP01_1312500 , PVX_084690 , PY17X_0614300
Google Scholar Search for all mentions of this gene