Normal numbers of ookinetes are produced. These ookinetes have a (light microscope) morphology that is comparable to wild type ookinetes. Ookinetes show a strong reduction (99%) in the formation of oocysts in A. stephensi mosquitoes. Ookinetes fail to invade midgut epithelial cells. Electron microscopic analyses demonstrated that the disruptant ookinetes could not access midgut epithelial cells by traversing the layer covering the cell surface.

Normal numbers of ookinetes are produced. These ookinetes have a (light microscope) morphology that is comparable to wild type ookinetes. Ookinetes show a strong reduction (99%) in the formation of oocysts in A. stephensi mosquitoes. Ookinetes fail to invade midgut epithelial cells. Ookinetes are severely impaired in the ability to migrate in vitro through a gel structure (Matrigel; see 'Additional information'). Ookinetes were able to move on the gel surface.

Normal numbers of ookinetes are produced. These ookinetes have a (light microscope) morphology that is comparable to wild type ookinetes. Ookinetes show a strong reduction (98%) in the formation of oocysts in A. stephensi mosquitoes. Ookinetes fail to associate with the midgut epithelium. Ookinetes showed a strongly reduced ability to glide productively.

See below

Ookinetes show strongly reduced forward gliding

Ookinetes show a strong reduction (99%) in the formation of oocysts in A. stephensi mosquitoes. The few oocysts that are produced, form normal numbers of sporozoites that are infectious to the mammalian host as determined by intravenous inoculation of sporozoites in rats.

Ookinetes show a strong reduction (99%) in the formation of oocysts in A. stephensi mosquitoes. The few oocysts that are produced, form normal numbers of sporozoites that are infectious to the mammalian host as determined by intravenous inoculation of sporozoites in rats.

Ookinetes show a strong reduction (98%) in the formation of oocysts in A. stephensi mosquitoes. Injection of in vitro cultured, mature ookinetes into the hemocoel and thereby by-passing the midgut wall resulted in normal development of oocysts and infectious sporozoites.

Ookinetes show strongly reduced forward gliding. No oocyst are formed.