PhenoPlasm

Disruptability [+]

Species	Disruptability	Reference	Submitter
P. berghei ANKA	Possible	RMgm-481	Imported from RMgmDB
P. berghei ANKA	Possible	PlasmoGEM (Barseq)	PlasmoGEM
P. berghei ANKA	Possible	RMgm-5182	Imported from RMgmDB

P. falciparum 3D7	Possible	USF piggyBac screen (Insert. mut.)	USF PiggyBac Screen

Mutant phenotypes [+]

Species	Stage	Phenotype	Reference	Submitter
P. berghei ANKA	Asexual	Difference from wild-type	RMgm-481 The phenotype of blood stages has not been analysed in detail. During the cloning procedure no evidence has been found for a delayed/affected growth/multiplication of the asexual blood stages. The generation of mutants lacking expression of metacaspase 2 indicates that metacaspase 2 is not essential for asexual blood stage development.	Imported from RMgmDB
P. berghei ANKA	Asexual	No difference	PlasmoGEM (Barseq)	PlasmoGEM
P. berghei ANKA	Asexual	Difference from wild-type	RMgm-5182 In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production	Imported from RMgmDB
P. berghei ANKA	Gametocyte	Difference from wild-type	RMgm-5182 In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production	Imported from RMgmDB
P. berghei ANKA	Ookinete	Difference from wild-type	RMgm-5182 In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production	Imported from RMgmDB
P. berghei ANKA	Oocyst	Difference from wild-type	RMgm-5182 In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production	Imported from RMgmDB
P. berghei ANKA	Sporozoite	Difference from wild-type	RMgm-5182 In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production	Imported from RMgmDB

More information

PlasmoDB	PBANKA_1302300
GeneDB	PBANKA_1302300
Malaria Metabolic Pathways	Localisation images Pathways mapped to
Previous ID(s)	PB000485.03.1, PB000485.03.2, PB000488.03.0, PB300386.00.0, PB405863.00.0, PBANKA_130230
Orthologs	PCHAS_1305500 , PF3D7_1438400 , PKNH_1244000 , PVP01_1268600 , PVX_118575 , PY17X_1306100
Google Scholar	Search for all mentions of this gene