Several IMC proteins co-localize with GAP45 during schizogony. (A) Using GFP as a fluorescence tag, the TMD proteins PFE1130w, MAl13P1.130, PFD1110w, as well as PF14_0578 reveal three distinct structures during ongoing schizogony. Commencing as cramplike structures (T1), they transform to small ring-shaped formations (T2) that toward the end of schizogony expand and are then equally distributed underneath the plasma membrane (T3). Enlargement of these distinct structures are marked (white square) and shown in second row (Zoom) for each cell line.Kono M, Herrmann S, Loughran NB, Cabrera A, Engelberg K, Lehmann C, Sinha D, Prinz B, Ruch U, Heussler V, Spielmann T, Parkinson J, Gilberger TW. Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite. Mol Biol Evol. 2012 Sep;29(9):2113-32. PMID:

Subcellular distribution of proteins predicted to be involved in invasion. All proteins were localized in schizonts (s) and free merozoites (m) using GFP-fusion proteins and grouped according to their predominant GFP localization: surface (green), inner membrane complex (turquoise),Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol. 2010 28(1):91-8.