Subcellular distribution of proteins predicted to be involved in invasion. All proteins were localized in schizonts (s) and free merozoites (m) using GFP-fusion proteins and grouped according to their predominant GFP localization. Shown are proteins that revealed cytosolic (PFC0945w, PFI1565w’PF11_0190 and PFL2100w, apicoplast (PFE0145w), mitochondrial and other subcellular distribution but may be involved in invasion.Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol. 2010 28(1):91-8.

Mitochondrial localization of GFP-tagged PfMDM2 within live Plasmodium falciparum parasites, directed by the protein’s N-terminus. Live imaging of the PfMDM2-GFP transgenic P. falciparum parasites under normal conditions. A distinct dot-like GFP signal was observed for PfMDM2, adjacent to the blue DAPI-stained nucleus, increasing in number with the progression of the life cycle. The truncated PfMDM2 protein lacking the N-terminus showed cytoplasmic distribution of the GFP signal.Vieira WA, Coetzer TL. Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues. Malar J. 2016 Jan 20;15(1):32.

Mitochondrial localization of GFP-tagged PfMDM2 within live Plasmodium falciparum parasites, directed by the protein’s N-terminus. Live co-localization of GFP-tagged PfMDM2 protein to the mitochondria of late schizont stage P. falciparum parasites under normal conditions and 30 min and 24 h after the termination of heat stress (41 °C for 2 h). R ring stage, T trophozoite stage, S schizont stage. Scale bar in bright field represents 2.5 μmVieira WA, Coetzer TL. Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues. Malar J. 2016 Jan 20;15(1):32.