| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
RMgm-753 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. berghei ANKA |
Possible |
RMgm-4620 | Imported from RMgmDB | |
| P. falciparum 3D7 |
Possible |
25843709 | Theo Sanderson, Wellcome Trust Sanger Institute | |
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. falciparum 3D7 |
Possible |
22698672 \"In the pfsdha disruptants, Fp mRNA and polypeptides were decreased, and neither SQR nor SDH activity of complex II was detected. The suppression of complex II caused growth retardation of the intraerythrocytic forms, suggesting that complex II contributes to intraerythrocytic parasite growth, although it is not essential for survival. The growth retardation in the pfsdha disruptant was rescued by the addition of succinate, but not by fumarate. This indicates that complex II functions as a quinol-fumarate reductase (QFR) to form succinate from fumarate in the intraerythrocytic parasite.\" |
Theo Sanderson, Francis Crick Institute | |
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
RMgm-753 | Imported from RMgmDB |
| P. berghei ANKA | Asexual |
No difference |
RMgm-4620 | Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
Difference from wild-type |
RMgm-753
Normal numbers of gametocytes are produced and male gamete formation (exflagellation) was normal. The conversion rate of female gametes to ookinetes in vitro of Pbsdha(-) was significantly reduced to 17% of wild type parasites. |
Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
Difference from wild-type |
RMgm-753
The conversion rate of female gametes to ookinetes in vitro of Pbsdha(-) was significantly reduced to 17% of wild type parasites. |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-753
The conversion rate of female gametes to ookinetes in vitro of Pbsdha(-) was significantly reduced to 17% of wild type parasites.No oocysts are formed. |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-4620
No formation of oocysts |
Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
Difference from wild-type |
RMgm-4620
No formation of oocysts; no formation of salivary gland sporozoites |
Imported from RMgmDB |
| P. berghei ANKA | Liver |
Difference from wild-type |
RMgm-4620
See Additional Information: Evidence for a role during liver stage development |
Imported from RMgmDB |
| P. falciparum 3D7 | Asexual |
No difference |
25843709 | Theo Sanderson, Wellcome Trust Sanger Institute |
| PlasmoDB | PBANKA_0518200 |
| GeneDB | PBANKA_0518200 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PB001099.03.0, PB001230.02.0, PB300675.00.0, PB300700.00.0, PBANKA_051820 |
| Orthologs | PCHAS_0518300 , PF3D7_1034400 , PKNH_0619600 , PVP01_0619500 , PVX_111005 , PY17X_0519300 |
| Google Scholar | Search for all mentions of this gene |