Disruptability [+]

Species Disruptability Reference Submitter
P. yoelii yoelii 17X
Possible
RMgm-1231 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. yoelii yoelii 17X Asexual
Difference from wild-type
RMgm-1231
Slightly reduced growth rate of blood stages
Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
No difference
RMgm-1231 Imported from RMgmDB
P. yoelii yoelii 17X Ookinete
No difference
RMgm-1231 Imported from RMgmDB
P. yoelii yoelii 17X Oocyst
No difference
RMgm-1231 Imported from RMgmDB
P. yoelii yoelii 17X Sporozoite
Difference from wild-type
RMgm-1231
Normal number of oocyst-derived sporozoites are produced. In contrast, salivary gland sporozoite numbers in pde(-) infected mosquitoes were ~55-fold lower than in wild type infected mosquitoes.Sporozoites show a strongly reduced gliding motility
Imported from RMgmDB
P. yoelii yoelii 17X Liver
Difference from wild-type
RMgm-1231
Normal number of oocyst-derived sporozoites are produced. In contrast, salivary gland sporozoite numbers in pde(-) infected mosquitoes were ~55-fold lower than in wild type infected mosquitoes.Sporozoites show a strongly reduced gliding motilityNo liver infection after infection of mice by mosquito bite. After intravenous injection of large numbers of sporozoites a low percentage of mice develop blood stage infections (with prolonged prepatent periods)
Imported from RMgmDB

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