Disruptability [+]

Species Disruptability Reference Submitter
P. yoelii yoelii 17X
Possible
RMgm-53 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-47 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) Imported from PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. yoelii yoelii 17X Asexual
No difference
RMgm-53 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
No difference
RMgm-53 Imported from RMgmDB
P. yoelii yoelii 17X Ookinete
No difference
RMgm-53 Imported from RMgmDB
P. yoelii yoelii 17X Oocyst
No difference
RMgm-53 Imported from RMgmDB
P. yoelii yoelii 17X Sporozoite
Difference from wild-type
RMgm-53
Normal numbers of midgut sporozoites are formed. Sporozoites do not display gliding motility. Sporozoites are strongly affected in their capacity to invade salivary glands. In wild type infected mosquitoes the proportion of total salivary gland-associated sporozoites released from within the glands was ~80% and in mutant infected mosquitoes only ~4%. Sporozoites are also affected in their infectivity to BALB/c mice (mutant sporozoites were at least 100 times less infective than WT sporozoites).
Imported from RMgmDB
P. yoelii yoelii 17X Liver
Difference from wild-type
RMgm-53
Sporozoites are affected in their infectivity to BALB/c mice (mutant sporozoites were at least 100 times less infective than WT sporozoites).
Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-47 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-47 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-47 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-47 Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-47
Normal numbers of midgut sporozoites are formed. Sporozoites do not display gliding motility. Sporozoites are strongly affected in their capacity to invade salivary glands (the number of salivary glandassociated, sporozoites per infected mosquito was 34 times smaller than in wild type). Sporozoites are also affected in their infectivity to Sprague-Dawley rats (~10,000 times less infective than wild type sporozoites).
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-47
Sporozoites are affected in their infectivity to Sprague-Dawley rats (~10,000 times less infective than wild type sporozoites).
Imported from RMgmDB

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