Disruptability [+]

Species Disruptability Reference Submitter
P. yoelii yoelii 17X
Possible
RMgm-305 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-159 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-145 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. yoelii yoelii 17X Asexual
No difference
RMgm-305 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
No difference
RMgm-305 Imported from RMgmDB
P. yoelii yoelii 17X Ookinete
No difference
RMgm-305 Imported from RMgmDB
P. yoelii yoelii 17X Oocyst
No difference
RMgm-305 Imported from RMgmDB
P. yoelii yoelii 17X Sporozoite
Difference from wild-type
RMgm-305
Normal numbers of midgut sporozoites are formed. Strong reduction in numbers of salivary gland sporozoites. Salivary gland sporozoite numbers for the mutant at day 14 after the infected meal were dramatically reduced (90% reduction) compared to wild type sporozoite numbers. Fluorescence microscopy observation of mutant-infected salivary glands suggested that the sporozoites were mainly attached to the glands but did not localize to the interior of the gland. Infection of mice by bite of infected mosquitoes did not result in blood stage infections.Injection of 10(5) oocyst-derived or 2 x 10(4) hemolymph-derived mutant sporozoites intravenously into mice, resulted blood-stage parasitemia in all mice on the same day (day 4) as the wild type-sporozoite control-injected mice.
Imported from RMgmDB
P. yoelii yoelii 17X Liver
Difference from wild-type
RMgm-305
Infection of mice by bite of infected mosquitoes did not result in blood stage infections.Injection of 10(5) oocyst-derived or 2 x 10(4) hemolymph-derived mutant sporozoites intravenously into mice, resulted blood-stage parasitemia in all mice on the same day (day 4) as the wild type-sporozoite control-injected mice.
Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-159 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-145 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-159 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-145 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-159 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-145 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-159 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-145 Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-159
Normal numbers of midgut sporozoites are formed. Strong reduction in numbers of salivary gland sporozoites. The deficiency to enter mosquito salivary glands was accompanied by substantial accumulation of viable sporozoites in the mosquito haemocoel.Strong reduction of gliding motility of oocyst-derived/hemolymph sporozoites. Invasion of hepatoma cells in vitro of purified oocyst-derived/hemolymph sporozoites was strongly reduced. Infection of mice/rats by mosquito bite or by inoculation of purified oocyst-derived/hemolymph sporozoites resulted in blood stage infections.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-145
Normal numbers of midgut sporozoites are formed. Strong reduction in numbers of salivary gland sporozoites. Strong reduction of gliding motility of oocyst-derived/hemolymph sporozoites. Infection of mice/rats by mosquito bite or by inoculation of purified oocyst-derived/hemolymph sporozoites resulted in blood stage infections.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-159
Invasion of hepatoma cells in vitro of purified oocyst-derived/hemolymph sporozoites was strongly reduced. Infection of mice/rats by mosquito bite or by inoculation of purified oocyst-derived/hemolymph sporozoites resulted in blood stage infections, comparable to wild type
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-145
Infection of mice/rats by mosquito bite or by inoculation of purified oocyst-derived/hemolymph sporozoites resulted in blood stage infections.
Imported from RMgmDB

More information

PlasmoDB PY17X_1310300
GeneDB PY17X_1310300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) null
Orthologs PBANKA_1306500 , PCHAS_1309700
Google Scholar Search for all mentions of this gene