Disruptability [+]

Species Disruptability Reference Submitter
P. yoelii yoelii 17X
Possible
RMgm-4708 Imported from RMgmDB
P. berghei ANKA
Refractory
RMgm-575 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. yoelii yoelii 17X Asexual
Difference from wild-type
RMgm-4708
Reduced growth/multiplication of asexual blood stages. Evidence is provided for reduced invasion of merozoites.
Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
Difference from wild-type
RMgm-4708
Normal production of male and female gametocytes. Normal egress of both male and female gametocytes from their host red blood cells after activation. Normal exflagellation rate (i.e. male gamete formation); however, exflagellating males showed (strongly) reduced formation of the characteristic exflagellation centers, i.e. exflagellating males surrounded/attached to uninfected cells.
Imported from RMgmDB
P. yoelii yoelii 17X Oocyst
Difference from wild-type
RMgm-4708
Strongly reduces formation of oocysts
Imported from RMgmDB
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

Subcellular distribution of proteins predicted to be involved in invasion. All proteins were localized in schizonts (s) and free merozoites (m) using GFP-fusion proteins and grouped according to their predominant GFP localization. Shown are proteins that revealed cytosolic (PFC0945w, PFI1565w’PF11_0190 and PFL2100w, apicoplast (PFE0145w), mitochondrial and other subcellular distribution but may be involved in invasion.Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol. 2010 28(1):91-8.

See original on MMP

More information