Disruptability [+]

Species Disruptability Reference Submitter
P. yoelii yoelii 17X
Possible
RMgm-838 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-837 Imported from RMgmDB
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) Imported from PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. yoelii yoelii 17X Asexual
Difference from wild-type
RMgm-838
All wild type (WT)-infected mice developed high parasitemias and died within 10 d of challenge. PyPNP and PyPNP-GFP parasites had no detectable impairment of intraerythrocytic development, but growth of these lines was impaired compared to that of WT parasites. None of the parasite lines lacking PNP were lethal to mice, and infected mice recovered from infection with no detectable parasitemia.
Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
No difference
RMgm-838 Imported from RMgmDB
P. yoelii yoelii 17X Oocyst
Difference from wild-type
RMgm-838
Strongly reduced numbers of oocysts. No salivary gland sporozoites.
Imported from RMgmDB
P. yoelii yoelii 17X Sporozoite
Difference from wild-type
RMgm-838
Strongly reduced numbers of oocysts. No salivary gland sporozoites.
Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-837 Imported from RMgmDB

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