PY17X_1031600 FeS assembly ATPase SufC, putative (SufC)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. yoelii yoelii 17X |
Possible |
RMgm-4781 | Imported from RMgmDB | |
| P. berghei ANKA |
Refractory |
RMgm-992 | Imported from RMgmDB | |
| P. berghei ANKA |
Refractory |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. yoelii yoelii 17X | Asexual |
No difference |
RMgm-4781 | Imported from RMgmDB |
| P. yoelii yoelii 17X | Gametocyte |
Difference from wild-type |
RMgm-4781
normal production of gametocytes; normal exflagellation |
Imported from RMgmDB |
| P. falciparum 3D7 | Asexual |
Refractory |
24086138 (Insert. mut.)
\"We disrupted the Suf pathway using a dominant negative mutant of SufC and showed that these parasites only survive when cultured in the presence of IPP. Furthermore, these parasites lack the apicoplast organelle and its organellar genome – a phenotype not observed when isoprenoid biosynthesis was specifically inhibited with fosmidomycin. Taken together, these results demonstrate that the Suf pathway has a fundamental role in maintaining the apicoplast organelle in addition to any role in isoprenoid biosynthesis.\" |
Theo Sanderson, Francis Crick Institute |
Imaging data (from Malaria Metabolic Pathways)
Plasmodium falciparum PfSufC is targeted to the apicoplast and may be peripherally membrane-associated. (A) Immunofluorescence localisation of SufC in the Plasmodium falciparum D10 ACPleader-GFP line. SufC signal (red, a), GFP (green, b) and their overlap (c) in two trophozoite examples. Parasite nuclei stained with DAPI (d), and the overall merged figure with the phase contrast scan (e) are shown. The signals obtained for a mitochondrial marker (MitoTracker Deep Red, a), SufC (green, b) and nucleus (blue, d). SufC was not localised to the mitochondrion.Kumar B, Chaubey S, Shah P, Tanveer A, Charan M, Siddiqi MI, Habib S. Interaction between sulphur mobilisation proteins SufB and SufC: Evidence for an iron-sulphur cluster biogenesis pathway in the apicoplast of Plasmodium falciparum. Int J Parasitol. 2011 41:991-9.
See original on MMPMore information
| PlasmoDB | PY17X_1031600 |
| GeneDB | PY17X_1031600 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | null |
| Orthologs | PBANKA_1029200 , PCHAS_1030000 , PF3D7_1413500 , PKNH_1344800 , PVP01_1335400 , PVX_085775 |
| Google Scholar | Search for all mentions of this gene |