Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
20807207 Theo Sanderson, Wellcome Trust Sanger Institute

Mutant phenotypes [+]

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Imaging data (from Malaria Metabolic Pathways)

GFP fluorescent images of parasites with GFP fused at the C terminus of the endogenous PfMYST showing the localization of PfMYST-GFP at ring, trophozoite and schizont stages. Nuclei were counterstained with Hoechst 33342. Triple merge indicates the merging of the light, GFP and Hoechst images of the same cells. GFP signal was detected throughout the IDC, and distributed in the whole parasite with increased intensity in the nuclear area.Miao J, Fan Q, Cui L, Li X, Wang H, Ning G, Reese JC, Cui L. The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum. Mol Microbiol. 2010 78(4):883-902.

See original on MMP

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