Disruptability [+]

Species Disruptability Reference Submitter
P. yoelii yoelii 17X
Possible
RMgm-842 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-617 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-516 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-515 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. yoelii yoelii 17X Asexual
No difference
RMgm-842 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
No difference
RMgm-842 Imported from RMgmDB
P. yoelii yoelii 17X Ookinete
No difference
RMgm-842 Imported from RMgmDB
P. yoelii yoelii 17X Oocyst
No difference
RMgm-842 Imported from RMgmDB
P. yoelii yoelii 17X Sporozoite
Difference from wild-type
RMgm-842
Normal numbers of salivary gland sporozoites.Sporozoites progressively lost infectivity after arrival in the salivary glands, becoming non-infectious within the following 8 days. A significant and progressively increasing fraction of sporozoites prematurely transformed inside the salivary glands into forms that resemble young liver stages
Imported from RMgmDB
P. yoelii yoelii 17X Liver
Difference from wild-type
RMgm-842
Normal numbers of salivary gland sporozoites.Sporozoites progressively lost infectivity after arrival in the salivary glands, becoming non-infectious to mice within the following 8 days.
Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-617 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-516 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-515 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-617
Increased numbers of (male) gametocytes
Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-516 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-515 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-617 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-516 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-515 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-617 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-516 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-515 Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-617
Normal numbers of oocysts and salivary gland sporozoites are formed. Sporozoites show a strongly reduced infectivity to mice both after intravenous inoculation of sporozoites or after infection by mosquito bite. Sporozoites showed normal invasion of HepG2 cells in vitro. However, both in vivo and in vitro liver stage development was strongly affected.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-516
Normal numbers of oocysts and salivary gland sporozoites are formed. Sporozoites are defective in gliding motility and hepatocyte cell traversal in vitro (see also 'Additional remarks phenotype' for further description of the sporozoites). Sporozoites are less infective to hepatocytes in vitro and to mice after intravenous inoculation of sporozoites. Sporozoites could not be transmitted to naive mice by mosquito bite.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-515
Normal numbers of oocysts and salivary gland sporozoites are formed. Sporozoites are defective in gliding motility and hepatocyte cell traversal in vitro (see also 'Additional remarks phenotype' for further description of the sporozoites). Sporozoites are less infective to hepatocytes in vitro and to mice after intravenous inoculation of sporozoites. Sporozoites could not be transmitted to naive mice by mosquito bite.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-617
Normal numbers of oocysts and salivary gland sporozoites are formed. Sporozoites show a strongly reduced infectivity to mice both after intravenous inoculation of sporozoites or after infection by mosquito bite. Sporozoites showed normal invasion of HepG2 cells in vitro. However, both in vivo and in vitro liver stage development was strongly affected.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-516
Normal numbers of oocysts and salivary gland sporozoites are formed. Sporozoites are defective in gliding motility and hepatocyte cell traversal in vitro. Sporozoites are less infective to hepatocytes in vitro and to mice after intravenous inoculation of sporozoites. Sporozoites could not be transmitted to naive mice by mosquito bite.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-515
Normal numbers of oocysts and salivary gland sporozoites are formed. Sporozoites are defective in gliding motility and hepatocyte cell traversal in vitro. Sporozoites are less infective to hepatocytes in vitro and to mice after intravenous inoculation of sporozoites. Sporozoites could not be transmitted to naive mice by mosquito bite.
Imported from RMgmDB

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