Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-301 Imported from RMgmDB
P. yoelii yoelii 17X
Possible
RMgm-5288 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-301 Imported from RMgmDB
P. yoelii yoelii 17X Asexual
No difference
RMgm-5288 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-301 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
No difference
RMgm-5288 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-301 Imported from RMgmDB
P. yoelii yoelii 17X Ookinete
Difference from wild-type
RMgm-5288
The aprp2 mutant showed normal asexual blood stage proliferation and gametocyte production. However, the mutant displayed a moderate decrease in mature ookinete formation. The mature-looking mutant ookinetes lost the crescent shape and had an impaired gliding ability compared to the WT. As a consequence, the aprp2 mutant produced significantly decreased numbers of midgut oocysts in the infected mosquitoes. These defects caused by depletion of either APRp2 were in concordance with the phenotype of the apr2 mutant.
Imported from RMgmDB
P. yoelii yoelii 17X Oocyst
Difference from wild-type
RMgm-5288
The mutant displayed a moderate decrease in mature ookinete formation. The mature-looking mutant ookinetes lost the crescent shape and had an impaired gliding ability compared to the WT. As a consequence, the aprp2 mutant produced significantly decreased numbers of midgut oocysts in the infected mosquitoes. These defects caused by depletion of either APRp2 were in concordance with the phenotype of the apr2 mutant.
Imported from RMgmDB

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