Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
20472690 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
No difference
20472690 Theo Sanderson, Wellcome Trust Sanger Institute

Imaging data (from Malaria Metabolic Pathways)

(A) Fluorescence pattern of PF13_0192-GFP. (B) Co-localisation IFA of PF13_0192-GFP with SBP1. (C) Fluorescence pattern of PF13_0191-GFP. Two panels are shown to demonstrate cells with (yellow arrows) and without additional foci of fluorescence in the host cell (ratio indicated in %, at least 50 cells were analysed on 3 occasions, standard deviation in brackets). (D) Bodipy-TR-C5-ceramide (Bodipy) stained parasites expressing PF13_0191-GFP. Protein structure in A and C indicated as in Figure 1. Nuclei were stained with DAPI. Size bars: 5 mm. PF13_0192-GFP was exported to foci in the host cell (A) that were confirmed to be Maurer’s clefts (B). PF13_0191-GFP localized to foci and mobile protrusions at the parasite periphery and in 20% (+/24%) of cells was also found in usually multiple mobile foci in the host cell with no apparent contact to the parasite periphery.Heiber A, Kruse F, Pick C, Grüring C, Flemming S, Oberli A, Schoeler H, Retzlaff S, Mesén-Ramírez P, Hiss JA, Kadekoppala M, Hecht L, Holder AA, Gilberger TW, Spielmann T. Identification of New PNEPs Indicates a Substantial Non-PEXEL Exportome and Underpins Common Features in Plasmodium falciparum Protein Export. PLoS Pathog. 2013 9(8):e1003546.

See original on MMP

More information

PlasmoDB PVX_082675
GeneDB PVX_082675
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) Pv082675
Orthologs PF3D7_1334300 , PKNH_1266100 , PVP01_1219800
Google Scholar Search for all mentions of this gene