Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
RMgm-551 Imported from RMgmDB
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
18614010
Integration confirmed by Southern blot
Theo Sanderson, Francis Crick Institute [Thank you to Thorey Jonsdottir for pointing out an error I made in transcribing this phenotype previously]
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Immunoelectron micrography on streptolysin-O permeablised mature trophozoite (36 h after invasion of the merozoites) infected cells. FEST is associated with Golgi-like structures in the red cell cytoplasm (a and b); vesicles in the red cell cytoplasm (c); the parasite plasma membrane (d) and membranous structures in the red cell cytoplasm (e); knobs in the parasitised red cell plasma membrane (f–h). A cross-section through a parasitised red cell is shown in (i). FEST is associated with membranous structures in the red cell and with the red cell membrane, particularly at parasite-induced knobs.Kun JF, Hibbs AR, Saul A, McColl DJ, Coppel RL, Anders RF. A putative Plasmodium falciparum exported serine/threonine protein kinase. Mol Biochem Parasitol. 1997 85:41-51. Copyright Elsevier 2009.

See original on MMP

More information