Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-1170 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-811 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. yoelii yoelii 17X
Possible
RMgm-4794 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-1170 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-811 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. yoelii yoelii 17X Asexual
No difference
RMgm-4794 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-1170 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
Difference from wild-type
RMgm-4794
enhanced production of gametocytes; (somewhat) reduced exflagellation
Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-1170 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-1170 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-1170 Imported from RMgmDB
P. berghei ANKA Liver
No difference
RMgm-1170 Imported from RMgmDB

Imaging data (from Malaria Metabolic Pathways)

Protein expression profile of selected P. falciparum proteases. IFAs using polyclonal mouse antisera directed against 12 of the proteases was used to demonstrate protein expression in the asexual blood stages (R, ring; T, trophozoite; iS, immature schizont; mS, mature schizont) and gametocytes (GC stages III, IV and V) as well as in macrogametes (MaG) at 20 min post-activation (in green). The asexual and the sexual blood sstages were visualized via immunolabelling with polyclonal rabbit antisera against PfMSP1 and Pfs230, respectively (in red). Hoechst 33342 staining was used to highlight the parasite nuclei (in blue). Bar, 5 μm. Results are representative of three to four independent experiments.Weißbach T, Golzmann A, Bennink S, Pradel G, Julius Ngwa C. Transcript and protein expression analysis of proteases in the blood stages of Plasmodium falciparum. Exp Parasitol. 2017 Mar 25. [Epub ahead of print]

See original on MMP

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