Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-1374 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-307 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-169 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
18452584 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. yoelii yoelii 17X
Possible
RMgm-4509 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-1374 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-307 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-169 Imported from RMgmDB
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-1374 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-307 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-169 Imported from RMgmDB
P. falciparum 3D7 Gametocyte
No difference
18452584 Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-307
Normal fertilisation rates and ookinete production. Ookinetes had a strongly reduced capacity to develop into oocysts (an oocyst production in Anopheles stephensi of only 2.2% of wild type oocysts). Mutant ookinetes had a greatly reduced gliding motility (speed).
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-169
Normal fertilisation rates and ookinete production. Ookinetes are not able to penetrate the cells of the midgut wall. The motility of ookinetes was reduced. The moving velocity of mutant parasites was much slower than that of wild type (wild type = 5.7 1.4 m/min, mutant = 0.6 0.1m/min)
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-307
Ookinetes had a strongly reduced capacity to develop into oocysts (an oocyst production in Anopheles stephensi of only 2.2% of wild type oocysts). Mutant ookinetes had a greatly reduced gliding motility (speed).
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-169
No oocyst formation.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-1374
No sporozoites in vivo
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-1374
No transmission by bite of infected mosquitoes
Imported from RMgmDB

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