Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Attenuated
21368162 (Conditional)
Asexual growth was inhibited when conditional knockdown was activated
Vasant Muralidharan, University of Georgia

Imaging data (from Malaria Metabolic Pathways)

Intraerythrocytic expression of Rpn6 and Rpn6ΔN. (A) Stages of the erythrocytic life cycle of Rpn6-RFA (Upper) and Rpn6ΔN-RFA (Lower) parasites observed by live fluorescence microscopy. Images left to right are phase, DAPI, GFP, and fluorescence merge. RFA - regulatable, fluorescent affinity (RFA) tag. Rpn6 and Rpn6ΔN were expressed in all intraerythrocytic life cycle stages and were located in the cytoplasm. Rpn6ΔN-RFA indicates deletion of the asparagine repeat. It is shown that the asparagine repeat is dispensable for protein expression, stability, and function.Muralidharan V, Oksman A, Iwamoto M, Wandless TJ, Goldberg DE. Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag. Proc Natl Acad Sci U S A. 2011 108:4411-6

See original on MMP

More information

PlasmoDB PKNH_1355800
GeneDB PKNH_1355800
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK14_0035c, PKH_134470
Orthologs PBANKA_1039600 , PCHAS_1040400 , PF3D7_1402300 , PVP01_1346500 , PVX_086315 , PY17X_1042100
Google Scholar Search for all mentions of this gene