Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Expression of ribonucleotide reductase small subunits PfR2 and PfR4. An asynchronous malarial parasite culture was immunostained with both anti-PfR2 and anti-PfR4 antibodies. Rabbit anti-PfR2 was detected with goat cy2 anti-rabbit conjugate (green). Mouse anti-PfR4 was detected with goat cy3 anti-mouse conjugate (red). The white arrows indicate sites of colocalization. Images were deconvolved using the Deltavision image restoration package. I, ring; II, trophozoite; and III, schizont. DNA was stained using DAPI. PfR2 and PfR4 showed distinct foci of cytoplasmic localization in all stages of intraerythrocytic maturation although some colocalization of both proteins can be seen, as evident from yellow merged spots.Bracchi-Ricard V, Moe D, Chakrabarti D. Two Plasmodium falciparum ribonucleotide reductase small subunits, PfR2 and PfR4, interact with each other and are components of the in vivo enzyme complex. J Mol Biol. 2005 347:749-58. Copyright Elsevier 2009.

See original on MMP

More information

PlasmoDB PKNH_1352500
GeneDB PKNH_1352500
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK14_0180c, PKH_134130
Orthologs PBANKA_1036600 , PCHAS_1037400 , PF3D7_1405600 , PVP01_1343200 , PVX_086155 , PY17X_1039000
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