Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

C. In both 3D7PfsD1-1 and 3D7PfsUba1 lines, GFP and ACP signals colocalise, suggesting that both are resident apicoplast proteins. Co-transfected 3D7sD1-1 with a construct encoding either the BTS of the apicoplast resident protein ACP or the mitochondrial targeting sequence of mitochondrial PfHsp60, fused to the red fluorescent protein DsRed. D. Fixed cells co-labelled with anti-GFP antibodies, ACP-DsRed PFB0385w and GFP signals co-localise, whilst HSP60-DsRed and GFP signal do not. Thus, the full-length PfsDer1-1-GFP fusion protein is transported to the apicoplast.Spork S, Hiss JA, Mandel K, Sommer M, Kooij TW, Chu T, Schneider G, Maier UG, Przyborski JM. An unusual ERAD-like complex is targeted to the apicoplast of Plasmodium falciparum. Eukaryot Cell. 2009 ;8(8):1134-45

See original on MMP

More information

PlasmoDB PKNH_1267400
GeneDB PKNH_1267400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK13_3380w, PKH_121970
Orthologs PBANKA_1347900 , PCHAS_1352500 , PF3D7_1333200 , PVP01_1221500 , PVX_082590 , PY17X_1352900
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