Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
RMgm-242 Imported from RMgmDB
P. falciparum 3D7
Possible
http://wiredspace.wits.ac.za/handle/10539/12599 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Possible
19040641
\"Deletion of this gene from P. falciparum had no effect on asexual parasite growth, but surprisingly also had no effect on gametocyte development or exflagellation, suggesting that these life cycle stages do not utilize host-derived glycerol as a carbon source. \"
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7
Possible
23954205
\"Disruption of the P. falciparum glycerol kinase gene produced viable parasites, but their growth was significantly reduced to 56.5±1.8% when compared to wild type parasites. (14)C-glycerol incorporation into the major phospholipids of the parasite membrane, phosphatidylcholine and phosphatidylethanolamine, was 48.4±10.8% and 53.1±5.7% relative to an equivalent number of wild type parasites.\"
Theo Sanderson, Francis Crick Institute

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Attenuated
http://wiredspace.wits.ac.za/handle/10539/12599 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7 Asexual
No difference
19040641
\"Deletion of this gene from P. falciparum had no effect on asexual parasite growth, but surprisingly also had no effect on gametocyte development or exflagellation, suggesting that these life cycle stages do not utilize host-derived glycerol as a carbon source. \"
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Asexual
Attenuated
23954205
\"Disruption of the P. falciparum glycerol kinase gene produced viable parasites, but their growth was significantly reduced to 56.5±1.8% when compared to wild type parasites. (14)C-glycerol incorporation into the major phospholipids of the parasite membrane, phosphatidylcholine and phosphatidylethanolamine, was 48.4±10.8% and 53.1±5.7% relative to an equivalent number of wild type parasites.\"
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Gametocyte
No difference
19040641
\"Deletion of this gene from P. falciparum had no effect on asexual parasite growth, but surprisingly also had no effect on gametocyte development or exflagellation, suggesting that these life cycle stages do not utilize host-derived glycerol as a carbon source. \"
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PKNH_1249400
GeneDB PKNH_1249400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK13_5170w, PKH_120240
Orthologs PBANKA_1364300 , PCHAS_1368900 , PF3D7_1351600 , PVP01_1203200 , PVX_083470 , PY17X_1370100
Google Scholar Search for all mentions of this gene