Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-5076 Imported from RMgmDB
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Possible
36477538
Essentially no males observed from straight knockout. In addition: \'We show that Md1 has a dual function stemming from two separate domains: in sex determination through its N terminus and in male development from its conserved C-terminal LOTUS/OST-HTH domain. We further identify a bistable switch at the md1 locus, which is coupled with sex determination and ensures that the male-determining gene is not expressed in the female lineage.\'
Theo Sanderson, Francis Crick Institute

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-5076 Imported from RMgmDB
P. falciparum 3D7 Asexual
No difference
36477538
Essentially no males observed from straight knockout. In addition: \'We show that Md1 has a dual function stemming from two separate domains: in sex determination through its N terminus and in male development from its conserved C-terminal LOTUS/OST-HTH domain. We further identify a bistable switch at the md1 locus, which is coupled with sex determination and ensures that the male-determining gene is not expressed in the female lineage.\'
Theo Sanderson, Francis Crick Institute
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-5076
No males, fertile females.
Imported from RMgmDB
P. falciparum 3D7 Gametocyte
Difference from wild-type
36477538
Essentially no males observed from straight knockout. In addition: \'We show that Md1 has a dual function stemming from two separate domains: in sex determination through its N terminus and in male development from its conserved C-terminal LOTUS/OST-HTH domain. We further identify a bistable switch at the md1 locus, which is coupled with sex determination and ensures that the male-determining gene is not expressed in the female lineage.\'
Theo Sanderson, Francis Crick Institute
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-5076
No males, fertile females.Complete (or nearly complete) loss in the ability to form oocysts in mosquitoes
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-5076
Complete (or nearly complete) loss in the ability to form oocysts in mosquitoes
Imported from RMgmDB

More information

PlasmoDB PKNH_1243500
GeneDB PKNH_1243500
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK14_1705w, PKH_126750
Orthologs PBANKA_1302700 , PCHAS_1305900 , PF3D7_1438800 , PVP01_1268200 , PVX_118550 , PY17X_1306500
Google Scholar Search for all mentions of this gene