Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Refractory
26198663 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

Immunodetection of the HA-tagged PfGluPho. Immunofluorescence shows a cytoplasmic localisation of the PfGluPho-HA with antiserum against the haemagglutinin (HA) antibody, consistent with bioinformatic analysis of the enzyme and its surrounding pathway. Labelling is excluded from the digestive vacuole, but some overlap is observed with the DAPI-stained nucleus. Representative parasites are shown from ~18 hour old Ring stages (ring), ~30 hour old trophozoite stages (Troph) and ~42 hour old schizont stages (Schiz).Allen SM, Lim EE, Jortzik E, Preuss J, Chua HH, MacRae JI, Rahlfs S, Haeussler K, Downton MT, McConville MJ, Becker K, Ralph SA. Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphoglucono-lactonase is a potential drug target. FEBS J. 2015 Jul 21. [Epub ahead of print] PMID: .

See original on MMP

More information

PlasmoDB PKNH_1228300
GeneDB PKNH_1228300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK14_2415c, PKH_125270
Orthologs PBANKA_1317500 , PCHAS_1320800 , PF3D7_1453800 , PVP01_1253200 , PVX_117790 , PY17X_1321300
Google Scholar Search for all mentions of this gene