Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
RMgm-1400 Imported from RMgmDB
P. berghei ANKA
Refractory
RMgm-323 Imported from RMgmDB
P. berghei ANKA
Refractory
RMgm-324 Imported from RMgmDB
P. falciparum 3D7
Refractory
18452584 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. yoelii yoelii 17X
Refractory
RMgm-4810 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7 Asexual
Egress defect
33500341
DiCre system \'GCα-null parasites cannot synthesize cGMP or mobilize calcium, a cGMP-dependent protein kinase (PKG)-driven requirement for egress. Using chemical complementation with a cGMP analogue and point mutagenesis of a crucial conserved residue within the P4-ATPase domain, we show that P4-ATPase activity is upstream of and linked to cGMP synthesis. Collectively, our results demonstrate that GCα is a critical regulator of PKG and that its associated P4-ATPase domain plays a primary role in generating cGMP for merozoite egress.\'
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PKNH_0936600
GeneDB PKNH_0936600
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK11_3790c, PKH_093620
Orthologs PBANKA_0910300 , PCHAS_0711600 , PF3D7_1138400 , PVP01_0939400 , PVX_092535 , PY17X_0911700
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