Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
28784333
SLI
Theo Sanderson, Wellcome Trust Sanger Institute

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Properties of proteins conserved , DnaJ and 11. (A) Saponin lysis during microscopy of a cell expressing PF11_0246. The identical infected RBC is shown before (top row) and after (bottom row) lysis with saponin. (B) Released merozoites of parasites expressing PF11_0246 show peripheral fluorescence (arrowhead) in addition to a prominent focus within the parasite. Saponin treatment did not release the PV fluorescence (A). In some merozoites a peripheral staining was detected after their release from the host cell, indicating that this protein may be integral to the PPM (B).(C,D) Saponin lysis during microscopy of a cell expressing DnaJ (C) or candidate 11; Saponin lysis of living parasites showed that the staining around the parasite was unaffected by lysis of the PVM. (D). The identical infected RBC is shown before (top rows) and after (bottom rows) lysis with saponin. Fluorescence around the parasite vanished after permeabilisation of the PVM. DIC, differential interference contrast; size bars: 5 mm.Khosh-Naucke M, Becker J, Mesén-Ramírez P, Kiani P, Birnbaum J, Fröhlke U, Jonscher E, Schlüter H, Spielmann T. Identification of novel parasitophorous vacuole proteins in P. falciparum parasites using BioID. Int J Med Microbiol. 2017 Jul 27. [Epub ahead of print] PMID: 28784333

See original on MMP

More information

PlasmoDB PKNH_0921300
GeneDB PKNH_0921300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK11_2060c, PKH_092100
Orthologs PBANKA_0924800 , PCHAS_0919600 , PF3D7_1123500 , PVP01_0924100 , PVX_091790 , PY17X_0926800
Google Scholar Search for all mentions of this gene