Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
RMgm-537 Imported from RMgmDB
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
24895132
Partial stalling at ring -> troph transition
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Attenuated
24895132
Partial stalling at ring -> troph transition
Theo Sanderson, Wellcome Trust Sanger Institute

Imaging data (from Malaria Metabolic Pathways)

CDPK7 may be present in the ER and vesicles. A IFA was performed to localize CDPK7 in various asexual stages of the parasite using antisera against CDPK7. R, rings; T, trophozoites; S, schizonts. B. Co-staining was done using antisera against CDPK7 and BiP on trophozoites (a) or with anti-RAP1 mAb on free merozoites (b). C. Immuno-EM performed on a trophozoite stage parasite indicated the presence of CDPK7 in ER and vesicular compartments (arrows). Various parasite organelles are indicated: FV, food vacuole; PM/PVM, parasite membrane/parasite vacuolar membrane; ER, Endoplasmic Reticulum; N, Nucleus.Kumar P, Tripathi A, Ranjan R, Halbert J, Gilberger T, Doerig C, Sharma P. Regulation of Plasmodium falciparum development by Calcium-Dependent Protein Kinase 7 (PfCDPK7). J Biol Chem. 2014 Jun 3. [Epub ahead of print]

See original on MMP

More information

PlasmoDB PKNH_0920900
GeneDB PKNH_0920900
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK11_2020w, PKH_092060
Orthologs PBANKA_0925200 , PCHAS_0919200 , PF3D7_1123100 , PVP01_0923700 , PVX_091770 , PY17X_0927200
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