Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Localization of XPD in P. falciparum 3D7 strain. A Different stages, i.e., ring, trophozoites, schizonts, and merozoites of the P. falciparum 3D7 strain, were fixed and stained with purified anti-PfXPDN antibodies. bright field image (i), image of cell stained with DAPI (ii), munofluorescently stained cell with anti-PfXPDN antibody (iii), merged images of ii and iii (iv), and merged images (v). PfXPD is mostly localized in the nuclear region during all the intraerythrocytic developmental stages (a–f). However, a partial cytoplasmic localization was also observed during trophozoite and schizont stages.Tajedin L, Tarique M, Tuteja R. Plasmodium falciparum XPD translocates in 5'to 3' direction, is expressed throughout the blood stages, and interacts with p44. Protoplasma. 2015 Feb 24. [Epub ahead of print]

See original on MMP

Colocalization of XPD and p44 in P. falciparum 3D7 strain. Different stages, i.e., ring, trophozoites, schizonts, and merozoites of the P. falciparum 3D7 strain, were fixed and stained with anti-PfXPDN and anti-Pfp44 antibodies. Bright field image (i), image of cell stained with DAPI (ii), immunofluorescently stained cell with anti-PfXPDN antibody (iii), (iv) immunofluorescently stained cell with anti Pfp44 antibody, and merged images (v). PfXPD and Pfp44 colocalized in the nucleus in all the developmental stages (a–f) particularly during ring and merozoite stages (a and f). Furthermore, both proteins (Pfp44 and PfXPD) colocalized partially in nucleus and cytoplasm during the trophozoite and schizont stages (b–e) of development, but it is interesting to note that Pfp44 was prominently visible in the cytoplasm (iv).Tajedin L, Tarique M, Tuteja R. Plasmodium falciparum XPD translocates in 5'to 3' direction, is expressed throughout the blood stages, and interacts with p44. Protoplasma. 2015 Feb 24. [Epub ahead of print]

See original on MMP

More information

PlasmoDB PKNH_0732800
GeneDB PKNH_0732800
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK9_3250w, PKH_073220
Orthologs PBANKA_0834900 , PCHAS_0835200 , PF3D7_0934100 , PVP01_0732800 , PVX_087010 , PY17X_0838300
Google Scholar Search for all mentions of this gene