Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-5217 Imported from RMgmDB
P. falciparum 3D7
Possible
27642791 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
Difference from wild-type
RMgm-5217
Reduced (14x) multiplication/growth of asexual blood stages
Imported from RMgmDB
P. falciparum 3D7 Asexual
Attenuated
27642791 Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-5217
Reduced gametocyte production. In 820cl1PbAT1-KO parasites, an average of 0.6% male gametocytemia compared to 1.32% was observed on day 3 following infection. Nearly no macrogametocytes could be detected in 820cl1PbAT1-KO, with an average of 0.07% compared to 1.71% in wild-type parasites, resulting in an altered sex ratio. The male gametocyte of 820cl1PbAT1-KO also appeared as empty and morphologically different from the wild-type ones through Giemsa staining.Reduced male gamete formation, defect in axoneme formation, no active exflagellation centers.
Imported from RMgmDB

More information

PlasmoDB PKNH_0621300
GeneDB PKNH_0621300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK10_3680c, PKH_062100
Orthologs PBANKA_0519800 , PCHAS_0520000 , PF3D7_1036800 , PVP01_0621200 , PVX_110920 , PY17X_0520900
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