Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-2 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-2 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-2 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-2
Slight inhibition of ookinete development (slight reduction in ookinete numbers in in vitro cultures); ookinetes do not form the typical clusters of multiple ookinetes in vitro
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-2
Slight inhibition of oocyst development (slight reduction in ookinete numbers in in Anopheles stephensi mosquitoes).
Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-2 Imported from RMgmDB
P. berghei ANKA Liver
No difference
RMgm-2 Imported from RMgmDB

Imaging data (from Malaria Metabolic Pathways)

Immunofluorescence assays, using specific antibodies, detected the proteins of interest (in green) in asexual blood stage (ABS) parasites, using MSP1 (in red). Nuclei were highlighted by Hoechst nuclear stain (in blue). Bar, 5 μm. Ngwa CJ, Scheuermayer M, Mair GR, Kern S, Brügl T, Wirth CC, Aminake MN, Wiesner J, Fischer R, Vilcinskas A, Pradel G. Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito. BMC Genomics. 2013 Apr 15;14:256

See original on MMP

More information

PlasmoDB PKNH_0615700
GeneDB PKNH_0615700
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK10_3150c, PKH_061530
Orthologs PBANKA_0515000 , PCHAS_0515100 , PF3D7_1031000 , PVP01_0616100 , PVX_111175 , PY17X_0516000
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