Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
21282103 Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
21282103 Theo Sanderson, Wellcome Trust Sanger Institute

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

PfnPrx is a nuclear protein. Top) Immuno-fluorescence using the mouse monoclonal anti-PfnPrx antibody demonstrates localisation of PfnPrx in the nucleus throughout the erythrocytic stage. Bottom) PfnPrx does not localise to the tight junction of merozoites in the process of invasion. Immunofluorescence with mouse monoclonal anti-nPrx and rabbit anti-RON4 antibody shows that PfnPrx is restricted to the nucleus in parasites invading a red blood cell. Richard D, Bartfai R, Volz J, Ralph SA, Muller S, Stunnenberg HG, Cowman AF. A genome-wide chromatin-associated nuclear from the malaria parasite Plasmodium falciparum. J Biol Chem. 2011 286(13):11746-55

See original on MMP

A. Endogenously tagging nPrx confirms its status as a nuclear protein. Epifluorescence microscopy on the 3D7nPrx-3’GFP line demonstrates that the tagged nPrx localises to the nucleus in all blood stages.B. PfnPrx is a nuclear protein. Immunoelectron microscopy using the rabbit anti-PfnPrx antibody on schizont stage parasites reveals that PfnPrx is in the electron dense nuclear periphery. The image shows a single merozoite located within a schizont.Richard D, Bartfai R, Volz J, Ralph SA, Muller S, Stunnenberg HG, Cowman AF. A genome-wide chromatin-associated nuclear from the malaria parasite Plasmodium falciparum. J Biol Chem. 2011 Jan 31. [Epub ahead of print]

See original on MMP

More information

PlasmoDB PKNH_0611700
GeneDB PKNH_0611700
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK10_2790c, PKH_061160
Orthologs PBANKA_0511400 , PCHAS_0511500 , PF3D7_1027300 , PVP01_0612400 , PVX_111355 , PY17X_0512500
Google Scholar Search for all mentions of this gene