Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-4143 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Difference from wild-type
RMgm-4143
Slightly reduced growth/multiplication of asexual blood stages.
Imported from RMgmDB
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-4143
Strongly reduced exflagellation (male gamete formation). Reduced DNA replication during male gamete formation (partially blocked at 1N; 50% of microgametocytes remained haploid; 40% of SOC1-KO microgametocytes reached the octoploid state).
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-4143
Strongly reduced exflagellation (male gamete formation). Reduced DNA replication during male gamete formation (partially blocked at 1N; 50% of microgametocytes remained haploid; 40% of SOC1-KO microgametocytes reached the octoploid state).
Imported from RMgmDB

Imaging data (from Malaria Metabolic Pathways)

Functional characterisation of three identified substrates of CDPK4. (B) SOC1-3xHA shows a diffuse cytoplasmic distribution (scale bar = 2 mm) but interacts withCDPK4 and proteins of the MCM complex. (F) SOC3 colocalises with axonemal a-tubulin in exflagellating gametes. Scale bar = 2 mm.Fang H, Klages N, Baechler B, Hillner E, Yu L, Pardo M, Choudhary J, Brochet M. Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during Plasmodium gametogenesis. Elife. 2017 May 8;6. pii: e26524. PMID: 28481199

See original on MMP

More information

PlasmoDB PKNH_0510500
GeneDB PKNH_0510500
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK4_1400c, PKH_052220
Orthologs PBANKA_0720200 , PCHAS_0729200 , PF3D7_0418100 , PVP01_0527500 , PVX_089995 , PY17X_0720200
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