Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Possible
36400305
\"We show using C-terminal truncations and gene knockouts of each of Pfczif1 and Pfczif2 that neither are essential for blood stage growth. However, they could not both be knocked out simultaneously, suggesting that at least one is needed for parasite growth in vitro. Immunofluorescence localisation of PfCZIF1 and PfCZIF2 indicated that both proteins occur in discrete foci on the periphery of the parasite\'s cytosol and biochemical assays suggest they are peripherally associated to a membrane. \"
Theo Sanderson, Francis Crick Institute

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7 Asexual
Possible
36400305
\"We show using C-terminal truncations and gene knockouts of each of Pfczif1 and Pfczif2 that neither are essential for blood stage growth. However, they could not both be knocked out simultaneously, suggesting that at least one is needed for parasite growth in vitro. Immunofluorescence localisation of PfCZIF1 and PfCZIF2 indicated that both proteins occur in discrete foci on the periphery of the parasite\'s cytosol and biochemical assays suggest they are peripherally associated to a membrane. \"
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PKNH_0501900
GeneDB PKNH_0501900
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK8_1900w, PKH_051380
Orthologs PBANKA_0712700 , PCHAS_0721800 , PF3D7_0818100 , PVP01_0517200 , PVX_089510 , PY17X_0712900
Google Scholar Search for all mentions of this gene