Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-360 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-359 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-360 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-359 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-359
Normal production of gametocytes and gametes. Northern analysis of mRNA of gametocytes showed a nearly complete loss of transcripts (mRNA) of genes that are translationally repressed (for example genes encoding the ookinete surface proteins P25, P28). Microarray analysis of mRNA of gametocytes showed a significant reduction (> 2x) of transcripts of a large number of genes.
Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-360
Normal production of gametocytes and gametes. Northern analysis of mRNA of gametocytes showed a nearly complete loss of transcripts (mRNA) of genes that are translationally repressed (for example genes encoding the ookinete surface proteins P25, P28). Microarray analysis of mRNA of gametocytes showed a significant reduction (> 2x) of transcripts of a large number of genes.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-360
Normal production of gametocytes and gametes. Normal fertilization. A complete block of development of fertilized female gametes (zygotes) into mature ookinetes.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-359
Normal production of gametocytes and gametes. Normal fertilization. A complete block of development of fertilized female gametes (zygotes) into mature ookinetes.
Imported from RMgmDB

More information