PF3D7_1440600 conserved Plasmodium protein, unknown function

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible		 USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible		 RMgm-4146 Imported from RMgmDB
P. berghei ANKA
Possible		 PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference		 RMgm-4146 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type		 RMgm-4146
No exflagellation (male gamete formation). Normal DNA replication during male gamete formation Normal axoneme in microgametocytes at 10 min. after activation but no exflagellation centers formed.
 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type		 RMgm-4146
No exflagellation (male gamete formation). Normal DNA replication during male gamete formation Normal axoneme in microgametocytes at 10 min. after activation but no exflagellation centers formed.
 Imported from RMgmDB

Imaging data (from Malaria Metabolic Pathways)

Functional characterisation of three identified substrates of CDPK4. (B) SOC1-3xHA shows a diffuse cytoplasmic distribution (scale bar = 2 mm) but interacts withCDPK4 and proteins of the MCM complex. (F) SOC3 colocalises with axonemal a-tubulin in exflagellating gametes. Scale bar = 2 mm.Fang H, Klages N, Baechler B, Hillner E, Yu L, Pardo M, Choudhary J, Brochet M. Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during Plasmodium gametogenesis. Elife. 2017 May 8;6. pii: e26524. PMID: 28481199

See original on MMP

More information

PlasmoDB PF3D7_1440600
GeneDB PF3D7_1440600
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PF14_0385
Orthologs PBANKA_1304500 , PCHAS_1307700 , PKNH_1241700 , PVP01_1266400 , PVX_118460 , PY17X_1308300
Google Scholar Search for all mentions of this gene