Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
RMgm-481 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-5182 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Difference from wild-type
RMgm-481
The phenotype of blood stages has not been analysed in detail. During the cloning procedure no evidence has been found for a delayed/affected growth/multiplication of the asexual blood stages. The generation of mutants lacking expression of metacaspase 2 indicates that metacaspase 2 is not essential for asexual blood stage development.
Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
Difference from wild-type
RMgm-5182
In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production
Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-5182
In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-5182
In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-5182
In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-5182
In the manuscript evidence is presented for: reduced growth of asexual blood stages, reduced gametocyte production (2.7 fold); reduced exflagellation, reduced ookinete formation, ookinete growth arrestment during early development, reduced oocyst production, reduced sporozoite production
Imported from RMgmDB

More information

PlasmoDB PF3D7_1438400
GeneDB PF3D7_1438400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PF14_0362, PF14_0363
Orthologs PBANKA_1302300 , PCHAS_1305500 , PKNH_1244000 , PVP01_1268600 , PVX_118575 , PY17X_1306100
Google Scholar Search for all mentions of this gene