Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Confocal microscopy of parasitized erythrocytes detected using primary antibody generated with the recombinant pf CTP synthetase, and visualised with a secondary antibody labeled with FITC. (A) Parasite infected erythrocytes (indicated by an arrow) have a much brighter fluorescence compared to non-infected erythrocyte cells, which appear with a low level green auto-fluorescence. (B) Overlaid images from red and green wavelength of parasitized and non-parasitized erythrocytes. The arrows indicate the locations of pfCTP synthetase. (C) Parasitized erythrocytes at different stages of the parasite life cycle: ring stage, trophozoite stage and schizont stage (left to right).Yuan P, Hendriks EF, Fernandez HR, O'Sullivan WJ, Stewart TS. Functional expression of the gene encoding cytidine triphosphate synthetase from Plasmodium falciparum which contains two novel sequences that are potential antimalarial targets. Mol Biochem Parasitol. 2005 143(2):200-8. PMID:

See original on MMP

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