Last updated 8 years ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
RMgm-401 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-401 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-401 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-401 Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-401
Normal numbers of ookinetes are formed that showed normal invasion/traversal of the midgut wall. The number of mutant oocysts was reduced, to 30% of the number in wild-type. The number of sporozoites per oocyst was comparable between the wild type and mutant parasites.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-401
The number of mutant oocysts was reduced, to 30% of the number in wild-type. The number of sporozoites per oocyst was comparable between the wild type and mutant parasites.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-401
The in vitro transformation rate of mutant sporozoites into 'spherical stages' (EEFs?) was reduced to 2050% of the wild-type rate (see also 'Additional remarks phenotype').
Imported from RMgmDB

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