Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Refractory
RMgm-335 Imported from RMgmDB
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Cellular localization in blood stage P. falciparum parasites of recombinant PfCCT. Immunofluorescence assays were performed on P. falciparum infected red blood cells at the schizont stage and revealed by an anti-PfCCT antibody (red). Nuclei were stained in blue with DAPI. Assays showed the presence of the endogenous PfCCT as a diffuse and dotted pattern. This suggested that PfCCT is localized in the cytoplasm with possibly some regions of higher concentration.Contet A, Pihan E, Lavigne M, Wengelnik K, Maheshwari S, Vial H, Douguet D, Cerdan R. Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening. FEBS Lett. 2015 589(9):992-1000.

See original on MMP

More information

PlasmoDB PF3D7_1316600
GeneDB PF3D7_1316600
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL13P1.86, PF13_0092
Orthologs PBANKA_1415100 , PCHAS_1416900 , PKNH_1417300 , PVP01_1417500 , PVX_122650 , PY17X_1416800
Google Scholar Search for all mentions of this gene