PF3D7_1243900 double C2-like domain-containing protein (DOC2)
Disruptability [+]
No information reported yet. Please press the '+' button above to add some.Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. falciparum 3D7 | Asexual |
Invasion defect |
22246776 (Knock down)
\"A conditional allele of the orthologous gene engineered into Plasmodium falciparum was also defective in microneme secretion. However, the major effect was on invasion, suggesting that microneme secretion is dispensable for Plasmodium egress.\" |
Theo Sanderson, Francis Crick Institute |
Imaging data (from Malaria Metabolic Pathways)
Localization of PfDOC2. Confocal immunofluorescence microscopy using anti-PfDOC2 antisera. (A) PfDOC2 labeled cells were visualized with Alexa 488 (green); (B) Blue: DAPI stains the nucleus of infected cells. (C) PfDOC2 and DAPI overlay. (D) DIC: differential interference contrast. PfDOC2 is expressed throughout the erythrocytic cycle and demonstrate that it is associated with membrane fractions and binds to calcium when it is part of these membranous structures.Jean S, Zapata-Jenks MA, Farley JM, Tracy E, Mayer DC. Plasmodium falciparum double C2 domain protein, PfDOC2, binds to calcium when associated with membranes. Exp Parasitol. 2014 144C:91-95. PMID: 24992295
See original on MMP
Localization of PfDOC2. Confocal immunofluorescence microscopy using anti-PfDOC2 antisera. (A) PfDOC2 labeled cells were visualized with Alexa 488 (green); (B) Blue: DAPI stains the nucleus of infected cells. (C) PfDOC2 and DAPI overlay. (D) DIC: differential interference contrast. PfDOC2 is localized within the parasite in a punctate manner reminiscent of vesicles but not with the erythrocyte membrane.Jean S, Zapata-Jenks MA, Farley JM, Tracy E, Mayer DC. Plasmodium falciparum double C2 domain protein, PfDOC2, binds to calcium when associated with membranes. Exp Parasitol. 2014 144:91-5.
See original on MMPMore information
| PlasmoDB | PF3D7_1243900 |
| GeneDB | PF3D7_1243900 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | 2277.t00422, MAL12P1.420, PFL2110c |
| Orthologs | PBANKA_1457200 , PCHAS_1459500 , PKNH_1463200 , PVP01_1461000 , PVX_101095 , PY17X_1459700 |
| Google Scholar | Search for all mentions of this gene |